Lessons learned from functional assessment of pluripotency-associated transcription factors during early embryogenesis and embryonic stem cells

Priscila Germany Corrêa da Silva, Marcelo Tigre Moura, Ludymila Furtado Cantanhêde, José Carlos Ferreira-Silva, Pábola Santos Nascimento, Roberta Lane de Oliveira Silva, José Pompeu dos Santos Filho, Marcos Antonio Lemos Oliveira

Resumo


Pluripotency-associated transcription factors (PATF) play significant roles during early embryogenesis and in embryonic stem (ES) cells, such as control of cell-cycle progression, modulation of cellular metabolism, and transcriptional control of differentiation-inducing factors. The review aims to describe the current understanding of how these PATFs contribute to the early embryo and the ES-cell phenotypes. By a selection of representative examples of such PATFs, their roles are described, and some interesting questions are presented concerning their activity in pluripotent cells which have yet to be addressed.

Palavras-chave


embryology; pluripotent; preimplantation development; totipotency

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Referências


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